The pharmacology of gastrointestinal nociceptive pathways

Curr Opin Pharmacol. 2002 Dec;2(6):642-9. doi: 10.1016/s1471-4892(02)00211-4.


The principal conscious sensations that arise from the gastrointestinal tract are discomfort and pain. Chronic visceral discomfort and pain are generally managed poorly with currently available pharmacological agents. Receptors and ion channels present on extrinsic visceral primary afferent (sensory) neurons are targets for the development of new pharmacological strategies for control of visceral pain.

Publication types

  • Review

MeSH terms

  • Animals
  • Central Nervous System / drug effects
  • Central Nervous System / physiology
  • Digestive System / drug effects*
  • Digestive System / innervation*
  • Digestive System / metabolism
  • Gastrointestinal Agents / pharmacology*
  • Humans
  • Inflammation / metabolism
  • Nerve Growth Factors / metabolism
  • Nociceptors / physiology*


  • Gastrointestinal Agents
  • Nerve Growth Factors