Tuberculosis (TB) is endemic and epidemic throughout the world. More people will die of TB this year then in any previous year in modern history. However, in the United States successful TB control programs have resulted in low morbidity and low mortality here. Globalization and immigration threatens this control potentially bringing the infection to a here-to-fore complacent United States. This article describes a unique partnership between a community health program of a School of Nursing and a local health department chest clinic to find, screen and treat a population of Hispanic immigrants otherwise difficult to reach because of legal, language, cultural and socioeconomic barriers. Working through community organizations and limiting, and/or eliminating cultural barriers accomplished a high level of screening and treatment in a population with a significant incidence of latent tuberculosis infection. The program was of great satisfaction to the students and faculty involved; the personnel of a seriously under-financed health department and the community participants involved.