Constitutive repression of E2F1 transcriptional activity through HDAC proteins is essential for neuronal survival

Ann N Y Acad Sci. 2002 Nov:973:438-42. doi: 10.1111/j.1749-6632.2002.tb04679.x.
No abstract available

MeSH terms

  • Animals
  • Cell Cycle Proteins*
  • Cell Survival / physiology*
  • DNA-Binding Proteins*
  • E2F Transcription Factors
  • E2F1 Transcription Factor
  • Enzyme Inhibitors / pharmacology
  • Genes, Reporter
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases / metabolism*
  • Hydroxamic Acids / pharmacology*
  • Luciferases / genetics
  • Mice
  • Neurons / cytology*
  • Neurons / physiology
  • Promoter Regions, Genetic
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Transcription Factors / genetics*
  • Transcription, Genetic / drug effects
  • Transcription, Genetic / physiology*

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • E2F1 Transcription Factor
  • E2f1 protein, mouse
  • Enzyme Inhibitors
  • Histone Deacetylase Inhibitors
  • Hydroxamic Acids
  • Transcription Factors
  • trichostatin A
  • Luciferases
  • Histone Deacetylases