Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-l-cysteine

Ann N Y Acad Sci. 2002 Nov;973:555-8. doi: 10.1111/j.1749-6632.2002.tb04700.x.

Abstract

Increased expression of the type I insulin-like growth factor receptor (IGF-1R) is associated with colon cancer, while the antioxidant N-acetyl-l-cysteine (NAC) is known to suppress colonic proliferation. We demonstrate that NAC down-regulates the expression of IGF-1R on three colorectal adenocarcinoma cell lines (HT29, SW480, and LoVo). NAC also abrogates the proliferative effect of IGF-I on HT29 cells. This indicates a novel mechanism for the therapeutic effects of NAC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcysteine / pharmacology*
  • Adenocarcinoma
  • Anticarcinogenic Agents / pharmacology*
  • Cell Division / drug effects
  • Colorectal Neoplasms
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Receptor, IGF Type 1 / genetics*
  • Tumor Cells, Cultured

Substances

  • Anticarcinogenic Agents
  • Receptor, IGF Type 1
  • Acetylcysteine