Genetics (molecular biology) and Meniere's disease

Otolaryngol Clin North Am. 2002 Jun;35(3):497-516. doi: 10.1016/s0030-6665(02)00018-x.

Abstract

COCH is not the FMD gene detected in our linkage study; furthermore, COCH and FMD are not allelic. The indications are that FMD is heterogenetic. The linkage analysis points to the possibility of one FMD mutation in one of the neighboring candidate genes on chromosome 14, and, with anticipation, possibly a triple repeat amplification. Recently, the myotonic dystrophy type 2 locus has been shown to contain an expanded tetranucleotide repeat [46], so the search for a similar repeat on 14q is indicated.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Animals
  • Chi-Square Distribution
  • Child
  • Chromosomes, Human, Pair 14 / genetics
  • Electroencephalography
  • Female
  • Gene Amplification
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • HLA Antigens / genetics
  • Humans
  • Male
  • Meniere Disease / complications
  • Meniere Disease / genetics*
  • Middle Aged
  • Migraine Disorders / complications
  • Migraine Disorders / genetics
  • Mutation
  • Pedigree
  • Risk
  • Surveys and Questionnaires
  • Trinucleotide Repeats

Substances

  • HLA Antigens