Etiology, pathophysiology of symptoms, and pathogenesis of Meniere's disease

Otolaryngol Clin North Am. 2002 Jun;35(3):529-45, vi. doi: 10.1016/s0030-6665(02)00019-1.

Abstract

Endolymphatic hydrops is the pathologic feature associated with Meniere's disease. The development of endolymphatic hydrops appears to arise from multifactorial inheritance with alteration of endolymphatic homeostasis. Various factors associated with the phenomenon of hydrops include functional or anatomic obstruction of endolymphatic flow, malabsorption of endolymph, genetic anomalies, vasodilation, allergy, viral infection, and autoimmunity.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity
  • Endolymph / physiology
  • Endolymphatic Hydrops / diagnosis
  • Endolymphatic Hydrops / etiology
  • Endolymphatic Sac / physiology
  • Guinea Pigs
  • Humans
  • Hypersensitivity / complications
  • Meniere Disease / etiology*
  • Meniere Disease / genetics
  • Meniere Disease / immunology
  • Meniere Disease / pathology
  • Meniere Disease / physiopathology*
  • Meniere Disease / surgery
  • Mutation
  • Temporal Bone / pathology
  • Vasopressins / physiology
  • Virus Diseases / complications

Substances

  • Vasopressins