Abstract
We report a case of late-onset pulmonary fibrosis involving the upper lobes that occurred in a young man treated with bleomycin for mediastinal germ-cell carcinoma. The parenchymal lesions became clinically apparent about two years after chemotherapy had been completed, with a slowly progressive course and sparing the lower lung fields during follow-up. Other possible diagnoses could be excluded on the basis of the patient's clinical history, laboratory tests and pathological findings.
MeSH terms
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Adult
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Antibiotics, Antineoplastic / administration & dosage
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Antibiotics, Antineoplastic / adverse effects*
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Antimetabolites, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Bleomycin / administration & dosage
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Bleomycin / adverse effects*
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Germinoma / drug therapy
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Humans
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Lung / diagnostic imaging
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Lung / drug effects*
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Lung / pathology
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Male
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Mediastinal Neoplasms / drug therapy
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Pulmonary Fibrosis / chemically induced*
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Pulmonary Fibrosis / diagnostic imaging
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Pulmonary Fibrosis / pathology
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Tomography, X-Ray Computed
Substances
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Antibiotics, Antineoplastic
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Antimetabolites, Antineoplastic
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Bleomycin