Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy

J Comput Assist Tomogr. 2002 Nov-Dec;26(6):948-51. doi: 10.1097/00004728-200211000-00016.

Abstract

We present a report of MRI and proton MR spectroscopy (MRS) findings in an adolescent patient with Down syndrome and Crohn disease treated with metronidazole. MRI revealed signal abnormalities within the corpus callosum, basal ganglia, and brainstem. Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment. Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Infective Agents / adverse effects*
  • Anti-Infective Agents / therapeutic use
  • Basal Ganglia / pathology*
  • Brain Chemistry
  • Brain Stem / pathology*
  • Corpus Callosum / pathology*
  • Crohn Disease / drug therapy*
  • Down Syndrome
  • Humans
  • Lactic Acid / analysis*
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Male
  • Metronidazole / adverse effects*
  • Metronidazole / therapeutic use

Substances

  • Anti-Infective Agents
  • Metronidazole
  • Lactic Acid