Body weight in mouse embryos specifies staging of tooth development

Connect Tissue Res. 2002;43(2-3):186-90. doi: 10.1080/03008200290000673.


Great intra- and interlitter variation in morphological stages is known to exist among mouse embryos of the same strain at a similar chronological stage. With the aim of searching for an easily measurable parameter that correlates well with tooth development, the morpho- and histodifferentiation of teeth were compared in embryos classified according to the embryonic day (ED) specified by wet body weight. The embryos and fetuses were harvested at 12-h intervals from ED12.5 until birth, weighed, fixed, and processed histologically. The tooth age was determined according to the developmental progress of the first molar, evaluated based on morpho- and histodifferentiation criteria. The data documented a better correlation between tooth morpho-histodifferentiation with the age/weight staging than with only the embryonic day. The cyto-differentiation of odontoblasts exhibited a high interlitter variability and was similar within specimens of the same litter, regardless of their body weight differences.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Weight*
  • Embryo, Mammalian / anatomy & histology
  • Embryo, Mammalian / physiology
  • Embryonic and Fetal Development
  • Mice / embryology*
  • Mice, Inbred ICR
  • Odontoblasts / cytology
  • Odontogenesis / physiology*