Effects of sea buckthorn (Hippophaë rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats

Fitoterapia. 2002 Dec;73(7-8):644-50. doi: 10.1016/s0367-326x(02)00221-6.


Oils from sea buckthorn (Hippophaë rhamnoides L.) seeds and berries have traditionally been used in the treatment of disorders of skin and mucosa in China. Compared with the negative control, oral administration of CO(2)-extracted seed and pulp oils, 7.0 ml x kg(-1) x day(-1) significantly reduced ulcer formation in water-immersion (P < 0.05) and reserpine-induced (P < 0.01) models in rats. In addition, administration of the two oils, 3.5 ml x kg(-1) x day(-1), significantly reduced the index of pylorus ligation-induced gastric ulcer (P < 0.05) and sped up the healing process of acetic acid-induced gastric ulcer (P < 0.01). The results suggested that the CO(2)-extracted sea buckthorn seed and pulp oils have both preventive and curative effects against experimental gastric ulcers in rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cimetidine
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Female
  • Hippophae / chemistry*
  • Male
  • Phytotherapy
  • Plant Oils / pharmacology*
  • Plant Oils / therapeutic use
  • Plant Structures / chemistry*
  • Rats
  • Rats, Sprague-Dawley
  • Reserpine
  • Seeds / chemistry*
  • Stomach Ulcer / drug therapy*


  • Plant Oils
  • Cimetidine
  • Reserpine