From endoderm formation to liver and pancreas development in zebrafish

Mech Dev. 2003 Jan;120(1):5-18. doi: 10.1016/s0925-4773(02)00327-1.


Recent studies in zebrafish have contributed to our understanding of early endoderm formation in vertebrates. Specifically, they have illustrated the importance of Nodal signaling as well as three transcription factors, Faust/Gata5, Bonnie and Clyde, and Casanova, in this process. Ongoing genetic and embryological studies in zebrafish are also contributing to our understanding of later aspects of endoderm development, including the formation of the gut and its associated organs, the liver and pancreas. The generation of transgenic lines expressing GFP in these organs promises to be particularly helpful in such studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Embryonic Induction
  • Endoderm*
  • Gastrula
  • Liver / embryology*
  • Mesoderm
  • Morphogenesis
  • Pancreas / embryology*
  • Zebrafish / embryology*