Minocycline-ethylenediaminetetraacetate Lock Solution for the Prevention of Implantable Port Infections in Children With Cancer

Clin Infect Dis. 2003 Jan 1;36(1):116-9. doi: 10.1086/344952. Epub 2002 Dec 11.

Abstract

In this prospective cohort study, minocycline-ethylenediaminetetraacetate (M-EDTA) was used as a lock solution in indwelling ports inserted in 14 children with cancer. No port infections, thrombotic events, or other adverse events were observed, compared with 10 port infections that occurred in 48 control patients whose ports were flushed with heparin. M-EDTA is a promising lock solution in long-term catheters.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Catheters, Indwelling
  • Chelating Agents / therapeutic use
  • Child
  • Child, Preschool
  • Cohort Studies
  • Drug Therapy, Combination
  • Edetic Acid / therapeutic use*
  • Female
  • Humans
  • Male
  • Minocycline / therapeutic use*
  • Neoplasms / complications*
  • Prospective Studies
  • Prosthesis-Related Infections / prevention & control*
  • Thrombosis / prevention & control*

Substances

  • Anti-Bacterial Agents
  • Chelating Agents
  • Edetic Acid
  • Minocycline