Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion

Angew Chem Int Ed Engl. 2002 Jan 18;41(2):278-81. doi: 10.1002/1521-3773(20020118)41:2<278::aid-anie278>3.0.co;2-a.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Cell Membrane
  • Circular Dichroism
  • Drug Design*
  • Enzyme-Linked Immunosorbent Assay
  • HIV Envelope Protein gp41 / chemistry*
  • HIV Envelope Protein gp41 / metabolism
  • HIV Fusion Inhibitors / chemistry*
  • HIV-1 / metabolism*
  • Humans
  • Membrane Fusion / drug effects*
  • Molecular Mimicry
  • Molecular Sequence Data
  • Peptides / chemistry*

Substances

  • HIV Envelope Protein gp41
  • HIV Fusion Inhibitors
  • Peptides