Inhibition of protein kinase A activity interferes with long-term, but not short-term, memory of conditioned taste aversions

Behav Neurosci. 2002 Dec;116(6):1070-4.

Abstract

The present experiments examined whether inhibition of cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) activity interferes with conditioned taste aversion (CTA) memories. Rats were centrally infused with the selective PKA inhibitor Rp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS) before conditioning. Direct infusions of Rp-cAMPS into the amygdala showed no interference with short-term memory but did show significant attenuation of long-term memory and more rapid extinction. Results suggest that PKA activity is involved in the consolidation of long-term memory of CTAs, and that the amygdala may be 1 site that is important for this activity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amygdala / drug effects
  • Amygdala / physiology*
  • Animals
  • Avoidance Learning
  • Cyclic AMP / administration & dosage
  • Cyclic AMP / analogs & derivatives*
  • Cyclic AMP / pharmacology
  • Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors
  • Cyclic AMP-Dependent Protein Kinases / pharmacology*
  • Enzyme Inhibitors / administration & dosage
  • Enzyme Inhibitors / pharmacology
  • Male
  • Memory, Short-Term / physiology*
  • Protein Kinase Inhibitors
  • Rats
  • Rats, Long-Evans
  • Stereoisomerism
  • Taste
  • Thionucleotides / administration & dosage
  • Thionucleotides / pharmacology

Substances

  • Enzyme Inhibitors
  • Protein Kinase Inhibitors
  • Thionucleotides
  • adenosine-3',5'-cyclic phosphorothioate
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases