Abstract
The present experiments examined whether inhibition of cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) activity interferes with conditioned taste aversion (CTA) memories. Rats were centrally infused with the selective PKA inhibitor Rp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS) before conditioning. Direct infusions of Rp-cAMPS into the amygdala showed no interference with short-term memory but did show significant attenuation of long-term memory and more rapid extinction. Results suggest that PKA activity is involved in the consolidation of long-term memory of CTAs, and that the amygdala may be 1 site that is important for this activity.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amygdala / drug effects
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Amygdala / physiology*
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Animals
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Avoidance Learning
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Cyclic AMP / administration & dosage
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Cyclic AMP / analogs & derivatives*
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Cyclic AMP / pharmacology
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Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors
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Cyclic AMP-Dependent Protein Kinases / pharmacology*
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Enzyme Inhibitors / administration & dosage
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Enzyme Inhibitors / pharmacology
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Male
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Memory, Short-Term / physiology*
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Protein Kinase Inhibitors
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Rats
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Rats, Long-Evans
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Stereoisomerism
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Taste
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Thionucleotides / administration & dosage
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Thionucleotides / pharmacology
Substances
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Enzyme Inhibitors
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Protein Kinase Inhibitors
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Thionucleotides
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adenosine-3',5'-cyclic phosphorothioate
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Cyclic AMP
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Cyclic AMP-Dependent Protein Kinases