Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice

BMC Pharmacol. 2002 Dec 19:2:21. doi: 10.1186/1471-2210-2-21. Epub 2002 Dec 19.


Background: As a folk remedy, Anethum graveolens seed (dill) is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum graveolens in mice.

Results: Gastric mucosal lesions were induced by oral administration of HCl (1 N) and absolute ethanol in mice. The acidity and total acid content of gastric juice were measured in pylorus-ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g/kg, i.p., (1.5, 6.16) and 6.98 g/kg, i.p., (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity and total acid content were reduced by the orally or intraperitoneally administration of the extracts.

Conclusions: The results suggest that A. graveolens seed extracts have significant mucosal protective and antisecretory effects of the gastric mucosa in mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anethum graveolens / chemistry*
  • Animals
  • Anti-Ulcer Agents / adverse effects
  • Anti-Ulcer Agents / therapeutic use*
  • Disease Models, Animal
  • Gastric Acid / metabolism
  • Hydrochloric Acid
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Plant Extracts / adverse effects
  • Plant Extracts / therapeutic use
  • Seeds / chemistry*
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / drug therapy*


  • Anti-Ulcer Agents
  • Plant Extracts
  • Hydrochloric Acid