A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes

J Biol Chem. 2003 Feb 28;278(9):7234-9. doi: 10.1074/jbc.M208992200. Epub 2002 Dec 18.


Eukaryotic genes are under the control of regulatory complexes acting through chromatin structure to control gene expression. Here we report the identification of a family of multiprotein corepressor complexes that function through modifying chromatin structure to keep genes silent. The polypeptide composition of these complexes has in common a core of two subunits, HDAC1,2 and BHC110, an FAD-binding protein. A candidate X-linked mental retardation gene and the transcription initiation factor II-I (TFII-I) are components of a novel member of this family of complexes. Other subunits of these complexes include polypeptides associated with cancer causing chromosomal translocations. These findings not only delineate a novel class of multiprotein complexes involved in transcriptional repression but also reveal an unanticipated role for TFII-I in transcriptional repression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blotting, Western
  • Cell Nucleus / metabolism
  • Chromatin / metabolism
  • Chromatography
  • Chromosomes, Human, X*
  • Genetic Linkage*
  • HeLa Cells
  • Histone Deacetylases / metabolism*
  • Humans
  • Immunoblotting
  • Intellectual Disability / genetics*
  • Mass Spectrometry
  • Models, Genetic
  • Peptides / chemistry
  • Precipitin Tests
  • Promoter Regions, Genetic
  • Protein Binding
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-fos / genetics
  • RNA, Small Interfering / metabolism
  • Time Factors
  • Transcription, Genetic
  • Transfection
  • Translocation, Genetic


  • Chromatin
  • Peptides
  • Proto-Oncogene Proteins c-fos
  • RNA, Small Interfering
  • Histone Deacetylases