Abstract
Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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3-Phosphoinositide-Dependent Protein Kinases
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Amino Acid Motifs
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Animals
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Enzyme Activation
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HSP70 Heat-Shock Proteins / metabolism
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Humans
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Isoenzymes / chemistry
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Isoenzymes / metabolism
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Phosphorylation
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Protein Kinase C / chemistry
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Protein Kinase C / metabolism*
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Protein Processing, Post-Translational / physiology
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Protein Serine-Threonine Kinases / metabolism
Substances
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HSP70 Heat-Shock Proteins
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Isoenzymes
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3-Phosphoinositide-Dependent Protein Kinases
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Protein Serine-Threonine Kinases
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Protein Kinase C