The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)

Semin Immunol. 2003 Feb;15(1):23-32. doi: 10.1016/s1044-5323(02)00125-2.


Multiple sclerosis (MS) is the commonest inflammatory demyelinating disease of the human central nervous system (CNS). In MS, CNS inflammation is associated with demyelination and axonal degeneration, which leads to clinical presentation. Expression and cellular localization of CCL2/MCP-1 and CCR2 in MS have been described in the three compartments: brain, cerebrospinal fluid (CSF) and blood. Evidence from descriptive, transgenic, knockout and neutralizing studies of experimental autoimmune encephalomyelitis (EAE) points towards a nonredundant role of CCL2 and CCR2 in the recruitment of inflammatory infiltrate into the CNS. Hence, CCL2 and CCR2 may be targets for specific and effective treatment in MS.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / metabolism
  • Cerebrospinal Fluid / metabolism
  • Chemokine CCL2 / cerebrospinal fluid
  • Chemokine CCL2 / immunology*
  • Chemokine CCL2 / metabolism
  • Encephalomyelitis, Autoimmune, Experimental / blood
  • Encephalomyelitis, Autoimmune, Experimental / cerebrospinal fluid
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Humans
  • Immunity, Cellular / immunology
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / immunology*
  • Receptors, CCR2
  • Receptors, Chemokine / blood
  • Receptors, Chemokine / immunology*
  • Receptors, Chemokine / metabolism


  • CCR2 protein, human
  • Chemokine CCL2
  • Receptors, CCR2
  • Receptors, Chemokine