Intraflagellar transport and cilia-dependent diseases

Trends Cell Biol. 2002 Dec;12(12):551-5. doi: 10.1016/s0962-8924(02)02410-8.


Intraflagellar transport involves the movement of large protein particles along ciliary microtubules and is required for the assembly and maintenance of eukaryotic cilia and flagella. Intraflagellar-transport defects in the mouse cause a range of diseases including polycystic kidney disease, retinal degeneration and the laterality abnormality situs inversus, highlighting the important role that motile, sensory and primary cilia play in vertebrates.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Cilia / metabolism*
  • Cilia / ultrastructure
  • Flagella / physiology*
  • Flagella / ultrastructure
  • Humans
  • Polycystic Kidney Diseases / metabolism*
  • Polycystic Kidney Diseases / ultrastructure
  • Retinal Degeneration / metabolism*
  • Situs Inversus / metabolism*

Associated data

  • OMIM/208500
  • OMIM/209900
  • OMIM/266900