A single-copy gene encodes Kex1, a serine endoprotease of Pneumocystis jiroveci

Infect Immun. 2003 Jan;71(1):571-4. doi: 10.1128/IAI.71.1.571-574.2003.

Abstract

We have cloned and characterized the kex1 gene of Pneumocystis jiroveci. Unlike the case for Pneumocystis carinii, in which the homologous PRT-1 genes are multicopy, kex1 is a single-copy gene encoding a protein homologous to fungal serine endoproteases, which localize to the Golgi apparatus. Thus, substantial biological differences can be seen among Pneumocystis species.

MeSH terms

  • Amino Acid Sequence
  • Ascomycota / enzymology*
  • Ascomycota / genetics
  • Fungal Proteins / chemistry
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Gene Dosage*
  • Molecular Sequence Data
  • Proprotein Convertases*
  • Saccharomyces cerevisiae Proteins*
  • Sequence Analysis, DNA
  • Serine Endopeptidases / chemistry
  • Serine Endopeptidases / genetics*
  • Serine Endopeptidases / metabolism
  • Subtilisins / chemistry
  • Subtilisins / genetics*
  • Subtilisins / metabolism

Substances

  • Fungal Proteins
  • Saccharomyces cerevisiae Proteins
  • Kex1 protein, Pneumocystis jirovecii
  • Proprotein Convertases
  • Serine Endopeptidases
  • Subtilisins
  • KEX2 protein, S cerevisiae

Associated data

  • GENBANK/AY127566
  • GENBANK/AY130996