The dual-function CD150 receptor subfamily: the viral attraction

Nat Immunol. 2003 Jan;4(1):19-24. doi: 10.1038/ni0103-19.

Abstract

The CD150 subfamily within the CD2 family is a growing group of dual-function receptors that have within their cytoplasmic tails a characteristic signaling motif. The ITSM (immunoreceptor tyrosine-based switch motif) enables these receptors to bind to and be regulated by small SH2 domain adaptor proteins, including SH2D1A (SH2-containing adaptor protein SH2 domain protein 1A) and EAT-2 (EWS-activated transcript 2). A major signaling pathway through the prototypic receptor in this subfamily, CD150, leads to the activation of interferon-gamma, a key cytokine for viral immunity. As a result, many viruses have designed strategies to usurp or alter CD150 functions. Measles virus uses CD150 as a receptor and Molluscum contagiosum virus encodes proteins that are homologous to CD150. Thus, viruses use CD150 subfamily receptors to create a favorable environment to elude detection and destruction. Understanding the CD150 subfamily may lead to new strategies for vaccine development and antiviral therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, CD
  • CD2 Antigens / genetics
  • CD2 Antigens / metabolism
  • Glycoproteins / genetics
  • Glycoproteins / metabolism*
  • Herpesvirus 4, Human / immunology
  • Humans
  • Immunoglobulins / genetics
  • Immunoglobulins / metabolism*
  • Measles virus / immunology
  • Models, Immunological
  • Poxviridae / immunology
  • Protein Binding
  • Receptors, Cell Surface
  • Receptors, Virus / metabolism
  • Signal Transduction
  • Signaling Lymphocytic Activation Molecule Family Member 1
  • Viruses / immunology
  • src Homology Domains

Substances

  • Antigens, CD
  • CD2 Antigens
  • Glycoproteins
  • Immunoglobulins
  • Receptors, Cell Surface
  • Receptors, Virus
  • SLAMF1 protein, human
  • Signaling Lymphocytic Activation Molecule Family Member 1