Possible maternal inheritance of a common obstructive urinary tract anomaly. Report of a case of a woman with multiple urinary tract infections and two sons with posterior urethral valves

J Reprod Med. 2002 Nov;47(11):962-4.

Abstract

Background: Posterior urethral valves (PUVs) are the most common cause of lower urinary tract obstruction in boys. Several prior reports have described PUV in siblings and twins, often with a variable phenotype.

Case: PUVs were found in two brothers. The first child had developmental delay, while the second had a branchial cleft cyst and an anteriorly rotated right ear. The children's mother had a history of numerous urinary tract infections of unknown etiology.

Conclusion: Though most cases of PUV appear to be sporadic, there are reports that suggest a partial genetic etiology, as our case suggests.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / diagnosis*
  • Abnormalities, Multiple / diagnostic imaging
  • Abnormalities, Multiple / genetics
  • Abnormalities, Multiple / pathology
  • Adult
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Siblings
  • Ultrasonography, Prenatal
  • Urethra / abnormalities*
  • Urethra / diagnostic imaging
  • Urethral Obstruction / complications
  • Urethral Obstruction / diagnosis*
  • Urethral Obstruction / diagnostic imaging
  • Urethral Obstruction / genetics
  • Urethral Obstruction / pathology
  • Urinary Tract Infections / etiology