DNA repair: bioinformatics helps reverse methylation damage

Curr Biol. 2002 Dec 23;12(24):R846-8. doi: 10.1016/s0960-9822(02)01350-7.

Abstract

Recent work has uncovered a novel DNA repair enzyme: the AlkB protein of Escherichia coli, which oxidises the methyl groups of 1-methyladenine and 3-methylcytosine to hydroxymethyl moieties; the oxidised groups are subsequently released as formaldehyde, regenerating the unmodified bases.

Publication types

  • Review

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / metabolism
  • Computational Biology / methods
  • Cytosine / analogs & derivatives*
  • Cytosine / metabolism
  • DNA Methylation*
  • DNA Repair / physiology*
  • Escherichia coli / genetics
  • Escherichia coli Proteins / physiology*
  • Mixed Function Oxygenases / physiology*

Substances

  • Escherichia coli Proteins
  • 3-methylcytosine
  • 1-methyladenine
  • Cytosine
  • Mixed Function Oxygenases
  • AlkB protein, E coli
  • Adenine