Regulation of endothelium-derived vasoactive autacoid production by hemodynamic forces

Trends Pharmacol Sci. 2003 Jan;24(1):24-9. doi: 10.1016/s0165-6147(02)00005-6.


Endothelial cells, which are situated at the interface between blood and the vessel wall, have a crucial role in controlling vascular tone and homeostasis, particularly in determining the expression of pro-atherosclerotic and anti-atherosclerotic genes. Many of these effects are mediated by changes in the generation and release of endothelium-derived autacoids [from the Greek autos (self) and akos (remedy)], which are generally short-lived and locally acting. In vivo, endothelial cells are constantly subjected to mechanical stimulation, which in turn determines the acute production of autacoids and the levels of autacoid-producing enzymes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autacoids / biosynthesis*
  • Endothelium, Vascular / metabolism*
  • Hemodynamics / physiology*
  • Humans
  • Vasoconstrictor Agents / pharmacology
  • Vasodilator Agents / pharmacology


  • Autacoids
  • Vasoconstrictor Agents
  • Vasodilator Agents