Synergistic lethal effect of a combination of phage lytic enzymes with different activities on penicillin-sensitive and -resistant Streptococcus pneumoniae strains

J M Loeffler; V A Fischetti

doi:10.1128/AAC.47.1.375-377.2003

Synergistic lethal effect of a combination of phage lytic enzymes with different activities on penicillin-sensitive and -resistant Streptococcus pneumoniae strains

Antimicrob Agents Chemother. 2003 Jan;47(1):375-7. doi: 10.1128/AAC.47.1.375-377.2003.

Authors

J M Loeffler¹, V A Fischetti

Affiliation

¹ Laboratory of Bacterial Pathogenesis, The Rockefeller University, New York, New York, 10021, USA.

Abstract

Pal and Cpl-1, two purified bacteriophage lytic enzymes, were tested for their in vitro activity, alone and in combination, against several serotypes of Streptococcus pneumoniae, including penicillin-resistant strains. The enzymes demonstrated synergism in their ability to cleave the bacterial peptidoglycan and thus may be more efficient for the prevention and elimination of pneumococcal colonization.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Penicillin Resistance
Serotyping / methods
Streptococcus Phages / enzymology*
Streptococcus pneumoniae / classification*
Streptococcus pneumoniae / drug effects