InterPreTS: protein interaction prediction through tertiary structure

Bioinformatics. 2003 Jan;19(1):161-2. doi: 10.1093/bioinformatics/19.1.161.


Summary: InterPreTS (Interaction Prediction through Tertiary Structure) is a web-based version of our method for predicting protein-protein interactions (Aloy and Russell, 2002, PROC: Natl Acad. Sci. USA, 99, 5896-5901). Given a pair of query sequences, we first search for homologues in a database of interacting domains (DBID) of known three-dimensional complex structures. Pairs of sequences homologous to a known interacting pair are scored for how well they preserve the atomic contacts at the interaction interface. InterPreTS includes a useful interface for visualising molecular details of any predicted interaction.


MeSH terms

  • Databases, Protein*
  • Imaging, Three-Dimensional / methods
  • Macromolecular Substances
  • Protein Binding
  • Protein Interaction Mapping / methods
  • Protein Structure, Tertiary
  • Proteins / chemistry*
  • Proteins / genetics
  • Sequence Alignment / methods*
  • Sequence Homology, Amino Acid
  • User-Computer Interface*


  • Macromolecular Substances
  • Proteins