Abstract
A systematic series of chemically modified coumarin dimmers has been synthesized and tested for their inhibitory activity against HIV-1 integrase. We observed that modified coumarin dimmers containing hydrophobic moiety on the linker display potent inhibitory activities.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Coumarins / chemical synthesis*
-
Coumarins / chemistry
-
Coumarins / pharmacology*
-
Dimerization
-
HIV Integrase / metabolism
-
HIV Integrase Inhibitors / chemical synthesis*
-
HIV Integrase Inhibitors / chemistry
-
HIV Integrase Inhibitors / pharmacology*
-
HIV-1 / drug effects
-
HIV-1 / enzymology*
-
Humans
-
Magnetic Resonance Spectroscopy
-
Molecular Structure
-
Structure-Activity Relationship
Substances
-
Coumarins
-
HIV Integrase Inhibitors
-
HIV Integrase