Percutaneous transluminal angioplasty for symptomatic middle cerebral artery stenosis: long-term follow-up

Cerebrovasc Dis. 2003;15(1-2):90-7. doi: 10.1159/000067135.


Background and objective: Although percutaneous transluminal angioplasty (PTA) is an effective treatment modality in the coronary and peripheral arterial diseases, its efficacy for intracranial atherosclerotic stenosis has not been verified. We assessed the long-term outcome of PTA for symptomatic middle cerebral artery (MCA) stenosis.

Methods: We performed PTA in 10 patients with symptomatic high-grade stenosis (>70%) on M1 segment of MCA, who had either recurrent transient ischemic attacks (TIAs) resistant to medical therapy or perfusion problems. PTA was performed with a microballoon (2-2.5 mm diameter and 10-13 mm length) without insertion of a stent. After PTA, we evaluated the possible occurrence of restenosis, which was defined as >50% stenosis on follow-up conventional angiogram or increased M1 flow velocity on follow-up transcranial doppler up to the baseline value.

Results: PTA was successfully performed in 9 patients without any serious complications. One patient had asymptomatic dissection. Residual stenosis was less than 50% in diameter in all the patients. During follow-up period (mean 34.5 months), TIAs did not recur in 6 of 7 patients who had had intractable TIAs. Two patients developed strokes, which were not referable to the index MCA lesions. Among the 6 patients who underwent follow-up conventional angiography or serial TCD, restenosis was noticed in 3 patients (50%).

Conclusion: Although restenosis is not uncommon, PTA for symptomatic MCA stenosis is a relatively safe procedure, and can be used to prevent recurrent TIAs or strokes in selected patients.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Angioplasty, Balloon*
  • Blood Flow Velocity / physiology
  • Cerebral Angiography
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Infarction, Middle Cerebral Artery / epidemiology
  • Infarction, Middle Cerebral Artery / physiopathology
  • Infarction, Middle Cerebral Artery / therapy*
  • Ischemic Attack, Transient / epidemiology
  • Ischemic Attack, Transient / physiopathology
  • Ischemic Attack, Transient / therapy
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Middle Cerebral Artery / diagnostic imaging
  • Postoperative Complications / diagnosis
  • Postoperative Complications / etiology
  • Recurrence
  • Risk Factors
  • Time
  • Tomography, Emission-Computed, Single-Photon
  • Treatment Outcome
  • Ultrasonography, Doppler, Transcranial