Abstract
To evaluate the effect of a calcium antagonist, nilvadipine, on cerebral blood flow and oxygen metabolism, we prospectively examined five ischaemic stroke patients, with both hypertension and chronic major cerebral artery occlusion, using positron emission tomography. The blood pressure showed a significant decrease after 3 months of nilvadipine treatment, the cerebral blood flow in the affected regions showed a significant increase and the oxygen extraction fraction showed a significant decrease. We conclude that nilvadipine is a safe and effective anti-hypertensive agent for patients with both hypertension and chronic major cerebral artery occlusion.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Aged
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Blood Pressure / drug effects
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Calcium Channel Blockers / administration & dosage
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Carotid Stenosis / complications
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Carotid Stenosis / diagnosis
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Carotid Stenosis / diagnostic imaging
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Carotid Stenosis / drug therapy
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Cerebrovascular Circulation / drug effects
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Female
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Follow-Up Studies
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Humans
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Hypertension / diagnosis
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Hypertension / diagnostic imaging*
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Hypertension / drug therapy*
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Hypertension / etiology
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Infarction, Middle Cerebral Artery / complications
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Infarction, Middle Cerebral Artery / diagnosis
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Infarction, Middle Cerebral Artery / diagnostic imaging
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Infarction, Middle Cerebral Artery / drug therapy
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Male
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Middle Aged
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Nifedipine / administration & dosage*
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Nifedipine / analogs & derivatives*
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Subtraction Technique
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Tomography, Emission-Computed / methods*
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Treatment Outcome
Substances
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Calcium Channel Blockers
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nilvadipine
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Nifedipine