Inflating cell numbers by Wnt

Mol Cell. 2002 Dec;10(6):1260-1. doi: 10.1016/s1097-2765(02)00801-8.

Abstract

One of the prominent biological phenomena controlled by Wnt signaling is the expansion of cells with predefined fates. In the November 27, 2002, issue of Cell, Rosenfeld and colleagues describe an example of Wnt-controlled proliferation during genesis of the cardiac outflow tract and the pituitary gland. As a downstream target gene of the Wnt cascade, the bicoid-related transcription factor Pitx2 directly drives proliferation in these tissues.

MeSH terms

  • Animals
  • Cell Division
  • Heart / physiology*
  • Homeodomain Proteins / metabolism
  • Mitogens / physiology
  • Myocardium / cytology
  • Nuclear Proteins*
  • Proto-Oncogene Proteins / physiology*
  • Signal Transduction / physiology*
  • Transcription Factors / metabolism
  • Transcription, Genetic
  • Wnt Proteins
  • Zebrafish Proteins*

Substances

  • Homeodomain Proteins
  • Mitogens
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Transcription Factors
  • Wnt Proteins
  • Zebrafish Proteins
  • homeobox protein PITX2