The transcription cycle in vivo. A blind watchmaker at work

Mol Cell. 2002 Dec;10(6):1264-6. doi: 10.1016/s1097-2765(02)00795-5.


Recent work by the Cook and Misteli laboratories addresses the issue of assembly and action of the transcription machinery. Live cell studies of RNA polymerases I (RNAP1) and II (RNAP2) indicate that transcription complexes are assembled in a stochastic fashion from freely diffusible subunits. This contrasts to models involving stable holo-complexes.

MeSH terms

  • DNA / genetics*
  • Kinetics
  • Models, Genetic
  • Periodicity
  • RNA Polymerase I / genetics
  • RNA Polymerase II / metabolism
  • Transcription, Genetic / physiology*


  • DNA
  • RNA Polymerase II
  • RNA Polymerase I