The jawbones, namely the maxilla and mandible, can be the sites of a multitude of neoplastic conditions. Given the variety of processes affecting this particular anatomic area, formulation of a precise diagnosis often can be challenging to the radiologist and the clinician, who may not be familiar with the imaging findings fundamental to diagnosis. Although advanced imaging methods have been developed, routine radiography remains the mainstay in the initial assessment of osseous lesions involving the jawbones. We review and summarize the imaging appearances of non-odontogenic tumors of the jawbones and illustrate example cases of these uncommon neoplasms of bone. Detailed patient history, physical examination, laboratory evaluation and histopathologic analysis are of paramount importance in diagnostic approach and, in most cases, are to be considered in the imaging evaluation of a given lesion. Correct interpretation of the imaging features of lesions involving the jawbones suggests the diagnosis, aids in presurgical planning and improves patient management.