Potassium channels as anti-epileptic drug targets

Neuropharmacology. 2002 Dec;43(7):1055-60. doi: 10.1016/s0028-3908(02)00237-x.

Abstract

It is estimated that up to 30% of epilepsy patients are poorly treated with available anti-epileptic drugs (AEDs). Thus, there is a medical need for new AEDs with novel mechanisms of action to serve as alternate or adjunct therapy for the treatment of drug-resistant or refractory epilepsy. One potential anti-epileptic mechanism that has not yet been exploited is K(+) channel opening. Considerable genetic, molecular, physiological and pharmacological evidence now exists to support a role for K(+) channels such as KCNQ2/Q3, Kv1.1, KATP and GIRK2 in the control of neuronal excitability and epileptogenesis. Evidence supporting these K(+) channels as novel AED targets will be reviewed in the following article.

Publication types

  • Review

MeSH terms

  • Animals
  • Anticonvulsants / administration & dosage*
  • Drug Delivery Systems / methods*
  • Humans
  • Potassium Channels / physiology*

Substances

  • Anticonvulsants
  • Potassium Channels