Dynamics of Ly49 expressing cytotoxic lymphocyte subsets in response to virus infection

Microbes Infect. 2002 Dec;4(15):1481-90. doi: 10.1016/s1286-4579(02)00031-x.


Viral infections induce first a loss and then an increase in natural killer (NK) and CD8(+) T cells. NK cells expressing Ly49G2 were selectively expanded by several viruses and poly I:C. CD8(+) T cells expressing Ly49G2 were selectively expanded by poly I:C and participated in the antigen-specific response to lymphocytic choriomeningitis virus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, Ly / metabolism*
  • Gene Expression Regulation
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / metabolism*
  • Lectins, C-Type
  • Lymphocytic choriomeningitis virus / immunology
  • Receptors, NK Cell Lectin-Like
  • T-Lymphocytes, Cytotoxic / immunology*
  • T-Lymphocytes, Cytotoxic / metabolism*
  • Virus Diseases / immunology*


  • Antigens, Ly
  • Lectins, C-Type
  • Receptors, NK Cell Lectin-Like