Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cells

Linda A Lieberman; Christopher A Hunter

doi:10.1016/s1286-4579(02)00036-9

Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cells

Microbes Infect. 2002 Dec;4(15):1531-8. doi: 10.1016/s1286-4579(02)00036-9.

Authors

Linda A Lieberman¹, Christopher A Hunter

Affiliation

¹ Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Rosenthal Bldg Room 226, 3800 Spruce Street, Philadelphia, PA 19104, USA.

PMID: 12505525
DOI: 10.1016/s1286-4579(02)00036-9

Abstract

The production of interferon gamma (IFN-gamma) by natural killer (NK) cells provides an innate mechanism of resistance to many intracellular pathogens. These events are regulated by multiple cytokines and transcription factors which have both positive and negative effects. This article reviews the role of cytokines, as well as costimulatory and signaling pathways, involved in NK cell responses associated with resistance to infection.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Communicable Diseases / immunology*
Interferon-gamma / biosynthesis*
Interferon-gamma / immunology*
Interleukin-12 / pharmacology
Killer Cells, Natural / drug effects
Killer Cells, Natural / immunology
Killer Cells, Natural / metabolism*
Lymphocyte Activation / drug effects
Signal Transduction* / drug effects

Substances

Interleukin-12
Interferon-gamma