Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cells

Microbes Infect. 2002 Dec;4(15):1531-8. doi: 10.1016/s1286-4579(02)00036-9.


The production of interferon gamma (IFN-gamma) by natural killer (NK) cells provides an innate mechanism of resistance to many intracellular pathogens. These events are regulated by multiple cytokines and transcription factors which have both positive and negative effects. This article reviews the role of cytokines, as well as costimulatory and signaling pathways, involved in NK cell responses associated with resistance to infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Communicable Diseases / immunology*
  • Interferon-gamma / biosynthesis*
  • Interferon-gamma / immunology*
  • Interleukin-12 / pharmacology
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology
  • Killer Cells, Natural / metabolism*
  • Lymphocyte Activation / drug effects
  • Signal Transduction* / drug effects


  • Interleukin-12
  • Interferon-gamma