Anti-prion antibodies for prophylaxis following prion exposure in mice

Neurosci Lett. 2003 Jan 23;336(3):185-7. doi: 10.1016/s0304-3940(02)01192-8.


Prion disease is characterized by a conformational change of the normal form of the prion protein (PrP(C)) to the scrapie-associated form (PrP(Sc)). Since the emergence of new variant Creutzfeldt-Jakob disease a potentially large human population is at risk for developing prion disease. Currently, no effective treatment or form of post-exposure prophylaxis is available for prion disease. We recently showed that active immunization with recombinant PrP prolongs the incubation period of scrapie. Here we show that anti-PrP antibodies following prion exposure are effective at increasing the incubation period of the infection. Stimulation of the immune system is an important therapeutic target for the prion diseases, as well as for other neurodegenerative illnesses characterized by abnormal protein conformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal / analysis
  • Creutzfeldt-Jakob Syndrome / immunology
  • Creutzfeldt-Jakob Syndrome / therapy
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Mice
  • Mice, Inbred Strains
  • PrPC Proteins / immunology*
  • PrPSc Proteins / immunology*
  • Prion Diseases / immunology*
  • Prion Diseases / therapy*
  • Prions / immunology*
  • Scrapie / immunology
  • Scrapie / therapy


  • Antibodies, Monoclonal
  • PrPC Proteins
  • PrPSc Proteins
  • Prions