The use of sildenafil in patients with erectile dysfunction in relation to diabetes mellitus--a study of 1,511 patients

Singapore Med J. 2002 Aug;43(8):387-90.

Abstract

Erectile dysfunction (ED) seriously impairs the quality of life. Patients with diabetes mellitus (DM) are prone to ED due to various factors, including vasculopathy, neuropathy and sex hormone abnormalities. This is a retrospective study involving 1,511 patients taking sildenafil. Patients with DM have significantly more comorbidities like hypertension and ischaemic heart disease. They are also more likely to be on medications which may affect erectile function, including various antihypertensive drugs. 77.9% of patients with DM reported success with sildenafil, as compared to 86.5% of patients without DM. A significant number of patients with DM require a higher dose of sildenafil as compared to those without DM.

Publication types

  • Multicenter Study

MeSH terms

  • Diabetes Complications
  • Diabetes Mellitus / drug therapy*
  • Humans
  • Impotence, Vasculogenic / complications
  • Impotence, Vasculogenic / drug therapy*
  • Male
  • Middle Aged
  • Phosphodiesterase Inhibitors / therapeutic use*
  • Piperazines / therapeutic use*
  • Purines
  • Retrospective Studies
  • Sildenafil Citrate
  • Singapore
  • Sulfones
  • Vasodilator Agents / therapeutic use*

Substances

  • Phosphodiesterase Inhibitors
  • Piperazines
  • Purines
  • Sulfones
  • Vasodilator Agents
  • Sildenafil Citrate