A web of circadian pacemakers

Cell. 2002 Dec 27;111(7):919-22. doi: 10.1016/s0092-8674(02)01225-4.


The mammalian circadian timing system is composed of almost as many individual clocks as there are cells. These countless oscillators have to be synchronized by a central pacemaker to coordinate temporal physiology and behavior. Recently, there has been some progress in understanding the relationship and communication mechanisms between central and peripheral clocks.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Clocks / physiology*
  • Circadian Rhythm / physiology*
  • Cues
  • Eukaryotic Cells / physiology*
  • Gene Expression Regulation / physiology*
  • Humans
  • Models, Animal
  • Suprachiasmatic Nucleus / physiology