Pattern recognition receptors: doubling up for the innate immune response

Cell. 2002 Dec 27;111(7):927-30. doi: 10.1016/s0092-8674(02)01201-1.

Abstract

Antigen presenting cells (macrophages and dendritic cells) express pattern recognition molecules that are thought to recognize foreign ligands during early phases of the immune response. The best known of these are probably the Toll-like receptors, but a number of other receptors are also involved. Several of these recognize endogenous as well as exogenous ligands, suggesting that they play a dual role in normal tissue function and host defense.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • Dendritic Cells / immunology*
  • Drosophila Proteins*
  • Humans
  • Lectins, C-Type*
  • Macrophage-1 Antigen / immunology
  • Macrophages / immunology*
  • Mannose-Binding Lectins*
  • Membrane Glycoproteins / immunology
  • Membrane Proteins / immunology
  • Nerve Tissue Proteins / immunology
  • Receptors, Cell Surface / immunology*
  • Receptors, Immunologic / immunology
  • Receptors, Lipoprotein*
  • Receptors, Scavenger
  • Scavenger Receptors, Class B
  • Toll-Like Receptors

Substances

  • Drosophila Proteins
  • Lectins, C-Type
  • Macrophage-1 Antigen
  • Mannose-Binding Lectins
  • Membrane Glycoproteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Receptors, Cell Surface
  • Receptors, Immunologic
  • Receptors, Lipoprotein
  • Receptors, Scavenger
  • Scarb1 protein, mouse
  • Scavenger Receptors, Class B
  • Toll-Like Receptors
  • dectin 1
  • mannose receptor