A hypothesis out-of-date. the diet-heart idea

J Clin Epidemiol. 2002 Nov;55(11):1057-63. doi: 10.1016/s0895-4356(02)00504-8.


An almost endless number of observations and experiments have effectively falsified the hypothesis that dietary cholesterol and fats, and a high cholesterol level play a role in the causation of atherosclerosis and cardiovascular disease. The hypothesis is maintained because allegedly supportive, but insignificant findings, are inflated, and because most contradictory results are misinterpreted, misquoted or ignored.

Publication types

  • Review

MeSH terms

  • Cholesterol / blood
  • Cholesterol, Dietary / adverse effects*
  • Coronary Disease / blood
  • Coronary Disease / etiology*
  • Diet, Atherogenic*
  • Dietary Fats / adverse effects
  • Epidemiologic Methods
  • Fatty Acids, Monounsaturated / administration & dosage
  • Humans
  • Research
  • Risk Factors


  • Cholesterol, Dietary
  • Dietary Fats
  • Fatty Acids, Monounsaturated
  • Cholesterol