Abstract
We have previously shown that interleukin (IL)-1 beta and other inflammatory cytokines are able to induce the expression of membrane and soluble intercellular adhesion molecule (ICAM)-1 on human myoblasts. In this paper we found that IL-10 and transforming growth factor (TGF)-beta 1 are able to prevent IL-1 beta-induced membrane and soluble ICAM-1 protein expression on human myoblasts, with different time courses. The effect of both cytokines is associated to a reduction in ICAM-1 mRNA. Our findings suggest that IL-10 and TGF-beta 1 are able to influence the inflammatory process in muscle tissue at least in part by means of control of membrane and soluble ICAM-1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Membrane / drug effects
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Cell Membrane / immunology
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Cell Membrane / metabolism
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Cells, Cultured
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Down-Regulation / drug effects
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Down-Regulation / immunology
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Graft Rejection / immunology*
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Graft Rejection / metabolism
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Graft Rejection / physiopathology
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Humans
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Intercellular Adhesion Molecule-1 / genetics
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Intercellular Adhesion Molecule-1 / immunology*
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Intercellular Adhesion Molecule-1 / metabolism
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Interleukin-1 / immunology*
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Interleukin-1 / metabolism
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Interleukin-10 / immunology
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Interleukin-10 / metabolism*
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Interleukin-10 / pharmacology
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Muscle Cells / drug effects
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Muscle Cells / immunology
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Muscle Cells / metabolism
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Muscle, Skeletal / immunology
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Muscle, Skeletal / metabolism
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Muscle, Skeletal / physiopathology
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Myoblasts, Skeletal / drug effects
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Myoblasts, Skeletal / immunology*
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Myoblasts, Skeletal / metabolism
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Myositis / immunology*
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Myositis / metabolism
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Myositis / physiopathology
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RNA, Messenger / drug effects
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RNA, Messenger / metabolism
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Reaction Time / drug effects
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Reaction Time / immunology
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Transforming Growth Factor beta / immunology
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Transforming Growth Factor beta / metabolism*
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Transforming Growth Factor beta / pharmacology
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Transforming Growth Factor beta1
Substances
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Interleukin-1
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RNA, Messenger
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TGFB1 protein, human
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Transforming Growth Factor beta
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Transforming Growth Factor beta1
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Intercellular Adhesion Molecule-1
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Interleukin-10