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, 162 (1), 353-4; author reply 354-5

Clonal Origin and Expansions in Neoplasms: Biologic and Technical Aspects Must Be Considered Together

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Clonal Origin and Expansions in Neoplasms: Biologic and Technical Aspects Must Be Considered Together

Lucia Pozo-Garcia et al. Am J Pathol.

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Figure 1.
Figure 1.
Cell kinetics and genetic changes during the clonal evolution of neoplasms. The first genetic abnormality during the neoplastic transformation is assumed to induce a clonal proliferation, the hallmark of neoplasms (bottom, left-hand bar). However, any other genetic changes will detect the lesion after the marker conversion only (eg, microsatellite instability or LOH, X2 in the diagram). Tumor tissue heterogeneity complicates the detection because results supportive of monoclonal proliferation (right cell field) will be obtained only if the abnormal cells (dark nuclei) are prevalent in the sample (gray cytoplasm). The expansion of genetically damaged cells (clone selection) is always due to disbalanced kinetic (↑ proliferation and/or ↓ apoptosis).

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