Eptifibatide-induced acute profound thrombocytopenia presenting as refractory hypotension

Catheter Cardiovasc Interv. 2003 Jan;58(1):76-9. doi: 10.1002/ccd.10392.

Abstract

A 61-year-old woman presented with acute coronary syndrome and was given heparin and eptifibatide in conjunction with coronary angioplasty. Shortly thereafter she became profoundly thrombocytopenic (platelets 2.0 x 10(9)/L) and developed severe refractory hypotension. Heparin-induced antibodies were not detected, but the patient developed strong eptifibatide-dependent antibodies specific for platelets that appear to explain both the thrombocytopenia and the hypotensive episode.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Angioplasty, Balloon, Coronary*
  • Coronary Angiography
  • Eptifibatide
  • Female
  • Humans
  • Hypotension / diagnostic imaging
  • Hypotension / etiology*
  • Middle Aged
  • Myocardial Infarction / diagnostic imaging
  • Myocardial Infarction / drug therapy*
  • Myocardial Infarction / surgery*
  • Peptides / adverse effects*
  • Peptides / therapeutic use*
  • Platelet Aggregation Inhibitors / adverse effects*
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / complications*
  • Thrombocytopenia / diagnostic imaging
  • Time Factors

Substances

  • Peptides
  • Platelet Aggregation Inhibitors
  • Eptifibatide