Abstract
A 61-year-old woman presented with acute coronary syndrome and was given heparin and eptifibatide in conjunction with coronary angioplasty. Shortly thereafter she became profoundly thrombocytopenic (platelets 2.0 x 10(9)/L) and developed severe refractory hypotension. Heparin-induced antibodies were not detected, but the patient developed strong eptifibatide-dependent antibodies specific for platelets that appear to explain both the thrombocytopenia and the hypotensive episode.
Copyright 2003 Wiley-Liss, Inc.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acute Disease
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Angioplasty, Balloon, Coronary*
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Coronary Angiography
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Eptifibatide
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Female
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Humans
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Hypotension / diagnostic imaging
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Hypotension / etiology*
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Middle Aged
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Myocardial Infarction / diagnostic imaging
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Myocardial Infarction / drug therapy*
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Myocardial Infarction / surgery*
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Peptides / adverse effects*
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Peptides / therapeutic use*
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Platelet Aggregation Inhibitors / adverse effects*
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Platelet Aggregation Inhibitors / therapeutic use*
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Thrombocytopenia / chemically induced*
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Thrombocytopenia / complications*
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Thrombocytopenia / diagnostic imaging
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Time Factors
Substances
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Peptides
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Platelet Aggregation Inhibitors
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Eptifibatide