Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)

Genes Chromosomes Cancer. 2003 Feb;36(2):205-6. doi: 10.1002/gcc.10159.

Abstract

Intravenous leiomyomatosis (IVL) is a rare smooth-muscle proliferation that is of special interest because of its quasi-malignant behavior. Our finding of a specific chromosomal aberration, a der(14)t(12;14)(q15;q24), in a second case of IVL suggests that it may be characteristic of IVL. We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15-qter and/or loss of 14q24-qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation.

MeSH terms

  • Adult
  • Chromosomes, Human, Pair 12 / genetics*
  • Chromosomes, Human, Pair 14 / genetics*
  • Cytogenetic Analysis / methods
  • Female
  • Humans
  • Leiomyoma / genetics
  • Leiomyomatosis / genetics*
  • Translocation, Genetic / genetics
  • Uterine Neoplasms / pathology
  • Vascular Neoplasms / genetics
  • Vascular Neoplasms / secondary