Developmental roles and clinical significance of hedgehog signaling

Curr Top Dev Biol. 2003;53:1-114. doi: 10.1016/s0070-2153(03)53002-2.


Cell signaling plays a key role in the development of all multicellular organisms. Numerous studies have established the importance of Hedgehog signaling in a wide variety of regulatory functions during the development of vertebrate and invertebrate organisms. Several reviews have discussed the signaling components in this pathway, their various interactions, and some of the general principles that govern Hedgehog signaling mechanisms. This review focuses on the developing systems themselves, providing a comprehensive survey of the role of Hedgehog signaling in each of these. We also discuss the increasing significance of Hedgehog signaling in the clinical setting.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Developmental Biology
  • Drosophila Proteins / genetics
  • Drosophila Proteins / physiology*
  • Gene Expression Regulation, Developmental*
  • Hedgehog Proteins
  • Humans
  • Trans-Activators / genetics
  • Trans-Activators / physiology*


  • Drosophila Proteins
  • Hedgehog Proteins
  • Trans-Activators
  • hh protein, Drosophila