Elevated plasma concentrations of nitric oxide, soluble thrombomodulin and soluble vascular cell adhesion molecule-1 in patients with systemic lupus erythematosus

Rheumatology (Oxford). 2003 Jan;42(1):117-22. doi: 10.1093/rheumatology/keg045.


Objective: To investigate the correlations among plasma concentrations of nitric oxide (NO), soluble thrombomodulin (sTM) and vascular cell adhesion molecule (sVCAM-1), and whether these three molecules are associated with renal involvement in patients with systemic lupus erythematosus (SLE).

Methods: Plasma NO concentrations of 73 SLE patients (35 with renal disease, RSLE patients; 38 without renal disease, SLE patients) and 28 age- and sex-matched healthy control subjects were measured by the non-enzymatic Griess assay, and sTM and sVCAM-1 by enzyme-linked immunosorbent assay.

Results: In RSLE patients, plasma nitrite concentrations were significantly higher than in control subjects (P=0.009) and correlated positively with plasma sTM, plasma creatinine and urea (all P<0.05). Plasma sTM and sVCAM-1 concentrations were significantly elevated in RSLE and SLE patients (both P<0.0001) compared with controls. Plasma sTM was significantly correlated with plasma sVCAM-1, and both were correlated with plasma creatinine and urea and the SLE Disease Activity Index (all P<0.05).

Conclusion: Elevated plasma NO, sTM, and sVCAM-1 concentrations have significant intercorrelations and are strongly associated with renal involvement in SLE.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • Case-Control Studies
  • Creatinine / blood
  • Female
  • Glomerulonephritis / blood*
  • Glomerulonephritis / complications
  • Humans
  • Lupus Erythematosus, Systemic / blood*
  • Lupus Erythematosus, Systemic / complications
  • Male
  • Middle Aged
  • Nitric Oxide / blood*
  • Nitrites / blood
  • Statistics, Nonparametric
  • Thrombomodulin / blood*
  • Urea / blood
  • Vascular Cell Adhesion Molecule-1 / blood*


  • Biomarkers
  • Nitrites
  • Thrombomodulin
  • Vascular Cell Adhesion Molecule-1
  • Nitric Oxide
  • Urea
  • Creatinine