Metastasis suppressors alter the signal transduction of cancer cells

Nat Rev Cancer. 2003 Jan;3(1):55-63. doi: 10.1038/nrc967.


Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without affecting its tumorigenicity have been identified. These affect important signal-transduction pathways, including mitogen-activated protein kinases, RHO, RAC and G-protein-coupled and tyrosine-kinase receptors. So how might we use this knowledge to improve the treatment of patients with cancer?

Publication types

  • Review

MeSH terms

  • Animals
  • Genes, Tumor Suppressor / physiology*
  • Humans
  • Neoplasms / metabolism*
  • Signal Transduction / physiology*