A paradigm for biological sulfur transfers via persulfide groups: a persulfide-disulfide-thiol cycle in 4-thiouridine biosynthesis

Chem Commun (Camb). 2002 Nov 21;(22):2708-9. doi: 10.1039/b208626c.


In support of the key features of sulfur transfer in the proposed mechanisms of 4-thiouridine generation, the enzyme ThiI can turn over only once in the absence of reductants of disulfide bonds, and Cys-456 of ThiI receives the sulfur transferred from the persulfide group of the sulfurtransferase IscS.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Disulfides / chemistry*
  • Molecular Structure
  • Sulfhydryl Compounds / chemistry*
  • Sulfides / chemistry*
  • Sulfur / chemistry*
  • Thiouridine / chemistry*
  • Thiouridine / metabolism*


  • Disulfides
  • Sulfhydryl Compounds
  • Sulfides
  • persulfides
  • Thiouridine
  • Sulfur