The molecular and genetic basis of colon cancer

Med Clin North Am. 2002 Nov;86(6):1467-95. doi: 10.1016/s0025-7125(02)00084-6.


Remarkable progress has been accomplished in understanding the molecular basis of genetic colon cancer syndromes including FAP and HNPCC, and their variants; of sporadic colon cancer; and of the rare hamartomatous polyp syndromes. This molecular progress now has to be translated into clinical progress in molecular diagnosis, and in pharmacologic therapy for colonic polyps and cancers. It is hoped that such progress will impact on the frequency and mortality of this very common and frequently fatal cancer.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenomatous Polyposis Coli / diagnosis
  • Adenomatous Polyposis Coli / genetics
  • Colonic Neoplasms / diagnosis
  • Colonic Neoplasms / genetics
  • Colonic Neoplasms / physiopathology*
  • Colonoscopy
  • Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • Genes, APC / physiology
  • Genes, p53 / genetics
  • Genes, ras / genetics
  • Humans
  • Microsatellite Repeats / physiology
  • Mutation